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CPG - Management of HIV Infection in Children - Feb 2008

19 July 2010

1. INTRODUCTION

By the end of 2006 there were estimated 2.3 million children globally below 15 years of age living with HIV with an estimated half a million new infections occurring in children for the year 2006.1 In addition, of the estimated 10 000 new infections that occurred daily worldwide among adults in 2006, 50% were among women.

In Malaysia, the cumulative number of reported cases of HIV infection at end 2006 was 76 389 with 5830 reported cases for 2006. While women constituted only 1.16% of total new cases for 1990, this increased to 15.0% for 2006.

Children below of age 12 years of age constituted 1.5% of total reported cases for 2006, those aged 13-19 years 1.0% and those aged 20-29 years 2.7%.2

The vast majority of paediatric HIV infections are acquired vertically. Estimates from studies of prevention of mother-to-child transmission (PMTCT) suggest that in non-breastfeeding populations, about 50% of all HIV infections occur in the days before delivery and during labour and another third occur during late labour and actual passage through the birth canal.

In breastfeeding populations, postnatal exposure could account for 40% of all transmissions. Studies suggest that transmission risk in infants who are exclusively breastfed is half that of infants who are given mixed feeding.3

Malaysia introduced antenatal counselling and testing for HIV in 1998 and utilized the Paediatric AIDS Clinical Trials Group (PACTG) 076 protocol for its PMTCT programme. From its introduction to the end of 2006, almost 3 million pregnant women were screened, representing 99.5% coverage of all recorded pregnancies. The prevalence of HIV-1 infection among pregnant women has remained an average of 0.036% over this time with an estimated average perinatal transmission rate of 3.7% (median 3.95%)2

In developed countries, the number of children of HIV positive mothers newly infected with HIV has decreased dramatically with a perinatal transmission rate of <1% - a result of antiretroviral (ARV) prophylaxis and the use of highly active antiretroviral therapy (HAART) for pregnant HIV infected mothers, the selection of lower risk delivery practices, neonatal ARV prophylaxis, and lower risk approaches to infant feeding. 

Although studies and advances in the management of HIV infection among children and adolescents have lagged behind those in adults, there have been substantial advances in the diagnosis, evaluation, treatment and monitoring of children exposed to and infected with HIV-1.


  arrowCPG Management of HIV Infection in Children.pdf (English - pdf - 2493 Kb)   



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